If you have been following aesthetic medicine trends over the past few months, you have surely come across the word polynucleotides. It is not a passing fad: it reflects a profound shift in the specialty, which has moved beyond simply filling or freezing and now aims to regenerate.
What exactly are they?
Polynucleotides (also known as PDRN) are highly purified DNA fragments, usually of salmon origin, that are biocompatible with human skin. When injected in microdoses, they act as a biological signal that stimulates fibroblasts —the cells that manufacture collagen and elastin—, improves deep hydration, and promotes tissue repair.
What do they improve?
Unlike a filler, the result is not volume: it is skin quality. Finer texture, elasticity, radiance, and a noticeable improvement in delicate areas such as the eye contour, the neck, and the hands. They are also used on the scalp as a supporting therapy in hair treatments.
Who are they for?
For anyone whose skin looks tired, thin, or dehydrated; for those starting to notice early laxity; and for those who want natural results without changing their features. They are usually prescribed in protocols of 2 to 4 sessions, spaced a few weeks apart, with periodic maintenance.
What matters most: medical hands
As with any injectable treatment, the key lies in the prior assessment: your skin, medical history, and goals define the protocol. In our practice we design a tailored regenerative plan, which may combine polynucleotides with biostimulators, skin boosters, or platelet-rich plasma depending on each case.
